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1

Pre-expression of a sulfhydryl oxidase significantly increases the yields of eukaryotic disulfide bond containing proteins expressed in the cytoplasm ofE.coli

Van Dat Nguyen, Feras Hatahet, Kirsi EH Salo, Eveliina Enlund, Chi Zhang, Lloyd W Ruddock

Journal:

Microbial Cell Factories

Year:

2011

Language:

english

File:

PDF, 1.12 MB

english, 2011

2

Beyond KDEL: The Role of Positions 5 and 6 in Determining ER Localization

Heli I. Alanen, Irina B. Raykhel, Marja J. Luukas, Kirsi E.H. Salo, Lloyd W. Ruddock

Journal:

Journal of Molecular Biology

Year:

2011

Language:

english

File:

PDF, 394 KB

english, 2011

3

Microscopic investigations of the interaction of proteins with surfaces

Jin-Hai Wang, Lloyd W. Ruddock, Anthony E.G. Cass

Journal:

Biosensors and Bioelectronics

Year:

1994

Language:

english

File:

PDF, 802 KB

english, 1994

4

The ligand-binding b′ domain of human protein disulphide-isomerase mediates homodimerization

Anne Katrine Wallis, Ateesh Sidhu, Lee J. Byrne, Mark J. Howard, Lloyd W. Ruddock, Richard A. Williamson, Robert B. Freedman

Journal:

Protein Science

Year:

2009

Language:

english

File:

PDF, 297 KB

english, 2009

5

Substrate recognition by the protein disulfide isomerases

Feras Hatahet, Lloyd W. Ruddock

Journal:

Year:

2007

Language:

english

File:

PDF, 1.56 MB

english, 2007

6

Bacitracin is not a specific inhibitor of protein disulfide isomerase

Anna-Riikka Karala, Lloyd W. Ruddock

Journal:

Year:

2010

Language:

english

File:

PDF, 198 KB

english, 2010

7

The human protein disulphide isomerase family: substrate interactions and functional properties

Ellgaard, Lars, Ruddock, Lloyd W.

Journal:

Year:

2005

Language:

english

File:

PDF, 721 KB

english, 2005

8

Specificity in substrate binding by protein folding catalysts: Tyrosine and tryptophan residues are the recognition motifs for the binding of peptides to the pancreas-specific protein disulfide isomerase PDIp

Lloyd W. Ruddock, Robert B. Freedman, Peter Klappa

Journal:

Protein Science

Year:

2000

Language:

english

File:

PDF, 358 KB

english, 2000

9

Gaining Access to ERp57 Function

Lloyd W. Ruddock

Journal:

Year:

2006

Language:

english

File:

PDF, 100 KB

english, 2006

10

Protein folding: A missing redox link in the endoplasmic reticulum

Robert B Freedman, Angela D Dunn, Lloyd W Ruddock

Journal:

Current Biology

Year:

1998

Language:

english

File:

PDF, 226 KB

english, 1998

11

Oxidative stress: Protein folding with a novel redox switch

Lloyd W Ruddock, Peter Klappa

Journal:

Current Biology

Year:

1999

Language:

english

File:

PDF, 56 KB

english, 1999

12

A pancreas-specific glycosylated protein disulphide-isomerase binds to misfolded proteins and peptides with an interaction inhibited by oestrogens

Peter Klappa, Thusnelda Stromer, Richard Zimmermann, Lloyd W. Ruddock, Robert B. Freedman

Journal:

Year:

1998

Language:

english

File:

PDF, 446 KB

english, 1998

13

Disruption of reducing pathways is not essential for efficient disulfide bond formation in the cytoplasm ofE. coli

Feras Hatahet, Dat Van Nguyen, Kirsi EH Salo, Lloyd W Ruddock

Journal:

Microbial Cell Factories

Year:

2010

Language:

english

File:

PDF, 543 KB

english, 2010

14

Efficient Peroxide-Mediated Oxidative Refolding of a Protein at Physiological pH and Implications for Oxidative Folding in the Endoplasmic Reticulum

Karala, Anna–Riikka, Lappi, Anna–Kaisa, Saaranen, Mirva J., Ruddock, Lloyd W.

Journal:

Antioxidants & Redox Signaling

Year:

2009

Language:

english

File:

PDF, 14.80 MB

english, 2009

15

The Role of Dehydroascorbate in Disulfide Bond Formation

Saaranen, Mirva J., Karala, Anna-Riikka, Lappi, Anna-Kaisa, Ruddock, Lloyd W.

Journal:

Antioxidants & Redox Signaling

Year:

2010

Language:

english

File:

PDF, 36.40 MB

english, 2010

16

Alternative Conformations of the x Region of Human Protein Disulphide-Isomerase Modulate Exposure of the Substrate Binding b’ Domain

Van Dat Nguyen, Katrine Wallis, Mark J. Howard, Antti M. Haapalainen, Kirsi E.H. Salo, Mirva J. Saaranen, Ateesh Sidhu, Rik K. Wierenga, Robert B. Freedman, Lloyd W. Ruddock, Richard A. Williamson

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.34 MB

english, 2008

17

Modulation of an Active-Site Cysteine pKa Allows PDI to Act as a Catalyst of both Disulfide Bond Formation and Isomerization

Anna-Riikka Karala, Anna-Kaisa Lappi, Lloyd W. Ruddock

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 330 KB

english, 2010

18

Two Endoplasmic Reticulum PDI Peroxidases Increase the Efficiency of the Use of Peroxide during Disulfide Bond Formation

Van Dat Nguyen, Mirva J. Saaranen, Anna-Riikka Karala, Anna-Kaisa Lappi, Lei Wang, Irina B. Raykhel, Heli I. Alanen, Kirsi E.H. Salo, Chih-chen Wang, Lloyd W. Ruddock

Journal:

Journal of Molecular Biology

Year:

2011

Language:

english

File:

PDF, 764 KB

english, 2011

19

Reexamination of the Role of Interplay between Glutathione and Protein Disulfide Isomerase

Anna-Kaisa Lappi, Lloyd W. Ruddock

Journal:

Journal of Molecular Biology

Year:

2011

Language:

english

File:

PDF, 638 KB

english, 2011

20

EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation

Silvia Olivari, Tito Cali, Kirsi E.H. Salo, Paolo Paganetti, Lloyd W. Ruddock, Maurizio Molinari

Journal:

Biochemical and Biophysical Research Communications

Year:

2006

Language:

english

File:

PDF, 296 KB

english, 2006

21

Modulation of glutaredoxin in the lung and sputum of cigarette smokers and chronic obstructive pulmonary disease

Mirva J Peltoniemi, Paula H Rytilä, Terttu H Harju, Ylermi M Soini, Kaisa M Salmenkivi, Lloyd W Ruddock, Vuokko L Kinnula

Journal:

Respiratory Research

Year:

2006

Language:

english

File:

PDF, 1.57 MB

english, 2006

22

Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients

Terttu H Harju, Mirva J Peltoniemi, Paula H Rytilä, Ylermi Soini, Kaisa M Salmenkivi, Philip G Board, Lloyd W Ruddock, Vuokko L Kinnula

Journal:

Respiratory Research

Year:

2007

Language:

english

File:

PDF, 1.27 MB

english, 2007

23

Low-Molecular-Weight Oxidants Involved in Disulfide Bond Formation

Ruddock, Lloyd W.

Journal:

Antioxidants & Redox Signaling

Year:

2012

Language:

english

File:

PDF, 307 KB

english, 2012

24

Does S -Methyl Methanethiosulfonate Trap the Thiol–Disulfide State of Proteins?

Karala, Anna–Riikka, Ruddock, Lloyd W.

Journal:

Antioxidants & Redox Signaling

Year:

2007

Language:

english

File:

PDF, 175 KB

english, 2007

25

Disulfide Bond Formation in the Cytoplasm

Saaranen, Mirva J., Ruddock, Lloyd W.

Journal:

Antioxidants & Redox Signaling

Year:

2013

Language:

english

File:

PDF, 451 KB

english, 2013

26

Topological Plasticity of Enzymes Involved in Disulfide Bond Formation Allows Catalysis in Either the Periplasm Or the Cytoplasm

Hatahet, Feras, Ruddock, Lloyd W.

Journal:

Journal of Molecular Biology

Year:

2013

Language:

english

File:

PDF, 805 KB

english, 2013

27

Peptidyl-Prolyl Cis/Trans Isomerasesby Andrzej Galat; Sylvie Riviere

Review by: Lloyd Ruddock

Journal:

Quarterly Review of Biology

Year:

2000

Language:

english

File:

PDF, 132 KB

english, 2000

28

Efficient export of prefolded, disulfide-bonded recombinant proteins to the periplasm by the Tat pathway in Escherichia coli CyDisCo strains

Matos, Cristina F. R. O., Robinson, Colin, Alanen, Heli I., Prus, Piotr, Uchida, Yuko, Ruddock, Lloyd W., Freedman, Robert B., Keshavarz-Moore, Eli

Journal:

Biotechnology Progress

Year:

2014

Language:

english

File:

PDF, 421 KB

english, 2014

29

Protein Disulfide Isomerase: A Critical Evaluation of Its Function in Disulfide Bond Formation

Hatahet, Feras, Ruddock, Lloyd W.

Journal:

Antioxidants & Redox Signaling

Year:

2009

Language:

english

File:

PDF, 129.44 MB

english, 2009

30

A pH-Dependent Conformational Change in the B-Subunit Pentamer of Escherichia coli Heat-Labile Enterotoxin: Structural Basis and Possible Functional Role for a Conserved Feature of the AB 5 Toxin Family †

Ruddock, Lloyd W., Webb, Helen M., Ruston, Stephen P., Cheesman, Caroline, Freedman, Robert B., Hirst, Timothy R.

Journal:

Year:

1996

Language:

english

File:

PDF, 512 KB

english, 1996

31

Solution Structure and Dynamics of ERp18, a Small Endoplasmic Reticulum Resident Oxidoreductase,

Rowe, Michelle L., Ruddock, Lloyd W., Kelly, Geoff, Schmidt, Jürgen M., Williamson, Richard A., Howard, Mark J.

Journal:

Year:

2009

Language:

english

File:

PDF, 4.57 MB

english, 2009

32

The C-Terminal Active Site Cysteine of Escherichia coli Glutaredoxin 1 Determines the Glutathione Specificity of the Second Step of Peptide Deglutathionylation

Saaranen, Mirva J., Salo, Kirsi E. H., Latva-Ranta, Maria K., Kinnula, Vuokko L., Ruddock, Lloyd W.

Journal:

Antioxidants & Redox Signaling

Year:

2009

Language:

english

File:

PDF, 13.21 MB

english, 2009

33

Protein Disulfide Isomerases from C. elegans are Equally Efficient at Thiol-Disulfide Exchange in Simple Peptide-Based Systems But Show Differences in Reactivity Towards Protein Substrates

Karala, Anna-Riikka, Psarrakos, Panagiotis, Ruddock, Lloyd W., Klappa, Peter

Journal:

Antioxidants & Redox Signaling

Year:

2007

Language:

english

File:

PDF, 201 KB

english, 2007

34

Efficient export of human growth hormone, interferon α2b and antibody fragments to the periplasm by the Escherichia coli Tat pathway in the absence of prior disulfide bond formation

Alanen, Heli I., Walker, Kelly L., Lourdes Velez Suberbie, M., Matos, Cristina F.R.O., Bönisch, Sarah, Freedman, Robert B., Keshavarz-Moore, Eli, Ruddock, Lloyd W., Robinson, Colin

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2015

Language:

english

File:

PDF, 943 KB

english, 2015

35

A Molecular Specificity Code for the Three Mammalian KDEL Receptors

Irina Raykhel, Heli Alanen, Kirsi Salo, Jaana Jurvansuu, Van Dat Nguyen, Maria Latva-Ranta and Lloyd Ruddock

Journal:

The Journal of Cell Biology

Year:

2007

Language:

english

File:

PDF, 3.25 MB

english, 2007

36

Systematic screening of soluble expression of antibody fragments in the cytoplasm of E. coli

Gaciarz, Anna, Veijola, Johanna, Uchida, Yuko, Saaranen, Mirva J., Wang, Chunguang, Hörkkö, Sohvi, Ruddock, Lloyd W.

Journal:

Microbial Cell Factories

Year:

2016

Language:

english

File:

PDF, 1.36 MB

english, 2016

37

Modulating Proteostasis: Peptidomimetic Inhibitors and Activators of Protein Folding

Hatahet, Feras, Ruddock, Lloyd

Journal:

Current Pharmaceutical Design

Year:

2009

Language:

english

File:

PDF, 555 KB

english, 2009

38

Mapping of the ligand-binding site on the b′ domain of human PDI: interaction with peptide ligands and the x-linker region

Byrne, Lee J., Sidhu, Ateesh, Wallis, A. Katrine, Ruddock, Lloyd W., Freedman, Robert B., Howard, Mark J., Williamson, Richard A.

Journal:

Biochemical Journal

Year:

2009

Language:

english

File:

PDF, 749 KB

english, 2009

39

Visualising geomorphology: Improving communication of data and concepts through engagement with the arts

Tooth, Stephen, Viles, Heather, Dickinson, Ant, Dixon, Simon, Falcini, Anna, Griffiths, Hywel, Hawkins, Harriet, Lloyd-Jones, Jessica, Ruddock, Julian, Thorndycraft, Varyl, Whalley, Brian

Journal:

Earth Surface Processes and Landforms

Year:

2016

Language:

english

File:

PDF, 1.38 MB

english, 2016

40

The pancreas-specific protein disulphide-isomerase PDIp interacts with a hydroxyaryl group in ligands

KLAPPA, Peter, FREEDMAN, Robert B., LANGENBUCH, Martina, LAN, Michael S., ROBINSON, Gary K., RUDDOCK, Lloyd W.

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 202 KB

english, 2001

41

pH-dependence of the dithiol-oxidizing activity of DsbA (a periplasmic protein thiol:disulphide oxidoreductase) and protein disulphide-isomerase: studies with a novel simple peptide substrate

RUDDOCK, Lloyd W., HIRST, Timothy R., FREEDMAN, Robert B.

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 428 KB

english, 1996

42

The pancreas-specific protein disulphide-isomerase PDIp interacts with a hydroxyaryl group in ligands

KLAPPA, Peter, FREEDMAN, Robert B., LANGENBUCH, Martina, LAN, Michael S., ROBINSON, Gary K., RUDDOCK, Lloyd W.

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 202 KB

english, 2001

43

Eukaryotic Chaperonin Containing T-Complex Polypeptide 1 Interacts with Filamentous Actin and Reduces the Initial Rate of Actin Polymerization in Vitro

Julie Grantham, Lloyd W. Ruddock, Anne Roobol and Martin J. Carden

Journal:

Cell Stress and Chaperones

Year:

2002

Language:

english

File:

PDF, 709 KB

english, 2002

44

Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease

Biterova, Ekaterina, Esmaeeli, Mariam, Alanen, Heli I., Saaranen, Mirva, Ruddock, Lloyd W.

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 4.40 MB

english, 2018

45

Complementarity determining regions and frameworks contribute to the disulfide bond independent folding of intrinsically stable scFv

Gąciarz, Anna, Ruddock, Lloyd W., Riggs, Paul D.

Journal:

Year:

2017

Language:

english

File:

PDF, 2.18 MB

english, 2017

46

Crystal structure of human anterior gradient protein 3

Nguyen, Van Dat, Biterova, Ekaterina, Salin, Mikko, Wierenga, Rik K., Ruddock, Lloyd W.

Journal:

Acta Crystallographica Section F Structural Biology Communications

Year:

2018

Language:

english

File:

PDF, 586 KB

english, 2018

47

Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation in FINCA disease

Paakkola, Teija, Salokas, Kari, Miinalainen, Ilkka, Lehtonen, Siri, Manninen, Aki, Kaakinen, Mika, Ruddock, Lloyd W, Varjosalo, Markku, Kaarteenaho, Riitta, Uusimaa, Johanna, Hinttala, Reetta

Journal:

Human Molecular Genetics

Year:

2018

Language:

english

File:

PDF, 1.26 MB

english, 2018

48

Structural analysis of human NHLRC2, mutations of which are associated with FINCA disease

Biterova, Ekaterina, Ignatyev, Alexander, Uusimaa, Johanna, Hinttala, Reetta, Ruddock, Lloyd W., Kobe, Bostjan

Journal:

Year:

2018

Language:

english

File:

PDF, 34.59 MB

english, 2018

49

The dimeric structure of wild-type human glycosyltransferase B4GalT1

Harrus, Deborah, Khoder-Agha, Fawzi, Peltoniemi, Miika, Hassinen, Antti, Ruddock, Lloyd, Kellokumpu, Sakari, Glumoff, Tuomo, André, Isabelle

Journal:

Year:

2018

Language:

english

File:

PDF, 2.95 MB

english, 2018

50

Efficient production of wild-type lipase B from Candida antarctica in the cytoplasm of Escherichia coli

Van Tassel, Lisette, Moilanen, Antti, Ruddock, Lloyd W.

Journal:

Protein Expression and Purification

Year:

2020

Language:

english

File:

PDF, 2.21 MB

english, 2020